当前位置: X-MOL 学术Biol. Bull. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception
Biology Bulletin ( IF 0.5 ) Pub Date : 2020-07-31 , DOI: 10.1134/s1062359020040020
S. A. Apryatin , V. A. Shipelin , N. V. Trusov , K. V. Mzhel’skaya , N. V. Kirbaeva , J. S. Soto , N. A. Riger , I. V. Gmoshinski

Abstract

We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.


中文翻译:

槲皮素对瘦素正常和受损小鼠的代谢和行为反应的影响

摘要

我们研究了槲皮素(Q)对遗传上易患肥胖症的雄性db / db小鼠的行为反应以及整体和代谢指标的影响,而C57Bl / 6J小鼠的饮食能量值过高。我们检查了前爪的握力,探索性活动,焦虑和短期记忆,以及整体和生化指标,以及瘦素,生长素释放肽和IL-10的含量。我们发现两种肥胖模型在积分和生化指标以及对Q治疗的行为反应方面存在差异。在db / db小鼠中,它们与Lepr基因的敲除有关编码瘦素受体的基因,阻止了瘦素的神经营养和调节功能。在临床实践中证明这种营养药物的剂量和时机合理时,应考虑检测到的Q的这些影响。
更新日期:2020-07-31
down
wechat
bug