Abstract

We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.

中文翻译：

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槲皮素对瘦素正常和受损小鼠的代谢和行为反应的影响

摘要

我们研究了槲皮素（Q）对遗传上易患肥胖症的雄性db / db小鼠的行为反应以及整体和代谢指标的影响，而C57Bl / 6J小鼠的饮食能量值过高。我们检查了前爪的握力，探索性活动，焦虑和短期记忆，以及整体和生化指标，以及瘦素，生长素释放肽和IL-10的含量。我们发现两种肥胖模型在积分和生化指标以及对Q治疗的行为反应方面存在差异。在db / db小鼠中，它们与Lepr基因的敲除有关编码瘦素受体的基因，阻止了瘦素的神经营养和调节功能。在临床实践中证明这种营养药物的剂量和时机合理时，应考虑检测到的Q的这些影响。