In this study, a nanogel-hydrogel hybrid was synthesized to improve drug delivery system performance. First, poly (acrylic acid-N-isopropylacrylamide) nanoparticles were synthesized using acrylic acid, N-isopropylacrylamide, sodium dodecyl sulfate, and MBA in the presence of APS as a radical initiator. Then the synthesized (A-N) nanogel was added to a solution of chitosan in acetic acid and (A-N) nanogel/ CTS-A hydrogel was synthesized in the presence of AA, MBA and ASP. (A-N) nanogel/ CTS-A hydrogel was characterized by IR, SEM, EDX, TEM, DLS, TGA, DTG and BET techniques. Doxorubicin (DOX) solution was used to evaluate drug loading capacity and the amount of drug-loaded was calculated using UV analysis. Drug release behavior was investigated by placing DOX-loaded (A-N) nanogel/ CTS-A at different temperature and pH ranges. Our research indicated the drug release for both carriers was controlled by diffusion mechanism but, increasing of temperature had not influenced the drug release mechanism. However, this study suggests that by trapping nanoparticles in a hydrogel system, drug carriers with higher absorption capacity and slower kinetic release can be created.

在这项研究中，合成了纳米凝胶-水凝胶杂合物以改善药物递送系统的性能。首先，在APS作为自由基引发剂的情况下，使用丙烯酸，N-异丙基丙烯酰胺，十二烷基硫酸钠和MBA合成聚（丙烯酸-N-异丙基丙烯酰胺）纳米粒子。然后将合成的（AN）纳米凝胶添加到壳聚糖在乙酸中的溶液中，并在AA，MBA和ASP的存在下合成（AN）纳米凝胶/ CTS-A水凝胶。（AN）纳米凝胶/ CTS-A水凝胶通过IR，SEM，EDX，TEM，DLS，TGA，DTG和BET技术表征。阿霉素（DOX）溶液用于评估载药量，并使用UV分析计算载药量。通过将载有DOX的（AN）纳米凝胶/ CTS-A置于不同的温度和pH范围来研究药物的释放行为。我们的研究表明，两种载体的药物释放均受扩散机制控制，但温度升高并未影响药物释放机制。但是，这项研究表明，通过将纳米颗粒捕获在水凝胶系统中，可以创建具有更高吸收能力和较慢动力学释放的药物载体。