Abstract
In this study, a nanogel-hydrogel hybrid was synthesized to improve drug delivery system performance. First, poly (acrylic acid-N-isopropylacrylamide) nanoparticles were synthesized using acrylic acid, N-isopropylacrylamide, sodium dodecyl sulfate, and MBA in the presence of APS as a radical initiator. Then the synthesized (A-N) nanogel was added to a solution of chitosan in acetic acid and (A-N) nanogel/ CTS-A hydrogel was synthesized in the presence of AA, MBA and ASP. (A-N) nanogel/ CTS-A hydrogel was characterized by IR, SEM, EDX, TEM, DLS, TGA, DTG and BET techniques. Doxorubicin (DOX) solution was used to evaluate drug loading capacity and the amount of drug-loaded was calculated using UV analysis. Drug release behavior was investigated by placing DOX-loaded (A-N) nanogel/ CTS-A at different temperature and pH ranges. Our research indicated the drug release for both carriers was controlled by diffusion mechanism but, increasing of temperature had not influenced the drug release mechanism. However, this study suggests that by trapping nanoparticles in a hydrogel system, drug carriers with higher absorption capacity and slower kinetic release can be created.
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References
Kurdtabar M, Koutenaee RN, Bardajee GR (2018) J Polym Res 25:119
Bardajee GR, Mizani F, Hosseini SS (2017) J Polym Res 24:48
Molinos M, Carvalho V, Silva DM, Gama FM (2012) Biomacromol 13:517–527
Pathania D, Verma C, Negi P, Tyagi I, Asif M, Kumar NS, Al-Ghurabi EH, Agarwal S, Gupta VK (2018) Carbohydr Polym 196:262–271
Pérez-Álvarez L, Ruiz-Rubio L, Artetxe B, dM Vivanco M, Gutiérrez-Zorrilla JM, Vilas-Vilela JL (2019) Carbohydr Polym 213:159–167
Rahimi S, Khoee S, Ghandi M (2018) Carbohydr Polym 201:236–245
Luckanagul JA, Pitakchatwong C, Bhuket PRN, Muangnoi C, Rojsitthisak P, Chirachanchai S, Wang Q, Rojsitthisak P (2018) Carbohydr Polym 181:1119–1127
Huang G, Liu Y, Chen L (2017) Drug Delivery 24(2):108–113
Zhang L, Wang L, Guo B, Ma PX (2014) Carbohydr Polym 103:110–118
Sundaram MN, Amirthalingam S, Mony U, Varma PK, Jayakumar R (2019) Int J Biol Macromol 129:936–943
Zhao J, Zhao X, Guo B, Ma PX (2014) Biomacromol 15:3246–3252. https://doi.org/10.1021/bm5006257
Wu C, Li R, Yin Y, Wang J, Zhang L, Zhong W (2017) Mater Sci Eng C 76:196–202
Wei S, Xie J, Luo Y, Ma Y, Tang S, Yue P, Yang M (2018) Carbohydr Polym 202:64–71
Moya-Ortega MD, Alvarez-Lorenzo C, Sigurdsson HH, Concheiro A, Loftsson T (2012) Carbohydr Polym 87:2344–2351
Sang G, Bardajee GR, Mirshokraie A, Didehban K (2018) Iran Polym J 27:137–144
Neamtu I, Rusu AG, Diaconu A, Nita LE, Chiriac AP (2017) Drug Delivery 24:539–557
Bardajee GR, Hooshyar Z (2018) Polym Bull 75:5403–5419
Zhao D, Shi X, Liu T, Lu X, Qiu G, Shea KJ (2016) Carbohydr Polym 151:1006–1011
Pei M, Jia X, Zhao X, Li J, Liu P (2018) Carbohydr Polym 183:131–139
Wali ARM, Zhou J, Ma S, He Y, Yue D, Tang JZ, Gu Z (2017) Int J Pharm 525:191–202
Ebrahimi E, Jarrahpour A, Heidari N, Sinou V, Latour C, Brunel JM, Zolghadr AR, Turos E (2016) Med Chem Res 25:247–262
Yang HN, Park JS, Jeon SY, Park K-H (2015) Carbohydr Polym 122:265–275
Kurdtabar M, Baghestani G, Bardajee GR (2019) Gold Bulletin 52:9–17
Seo S, Lee C-S, Jung Y-S, Na K (2012) Carbohydr Polym 87:1105–1111
Bardajee GR, Hooshyar Z, Farsi M, Mobini A, Sang G (2017) Mater Sci Eng C 72:558–565
Liang Y, Zhao X, Ma PX, Guo B, Du Y, Han X (2019) J Colloid Interface Sci 536:224–234
Sarika P, Kumar PA, Raj DK, James NR (2015) Carbohydr Polym 119:118–125
Karami B, Farahi M, Farmani N, Tanuraghaj HM (2016) New J Chem 40:1715–1719
Wu T, Liao W, Wang W, Zhou J, Tan W, Xiang W, Zhang J, Guo L, Chen T, Ma D (2018) Carbohydr Polym 197:403–413
Hemmati K, Masoumi A, Ghaemy M (2016) Carbohydr Polym 136:630–640
Esmaeilpour M, Sardarian AR, Jarrahpour A, Ebrahimi E, Javidi J (2016) RSC Adv 6:43376–43387
Yang WJ, Zhou P, Liang L, Cao Y, Qiao J, Li X, Teng Z, Wang L (2018) ACS Appl Mater Interfaces 10:18560–18573
Qu J, Zhao X, Ma PX, Guo B (2018) Acta Biomater 72:55–69
Sultana F, Manirujjaman M, Imran-Ul-Haque MA, Sharmin S (2013) J Appl Pharm Sci 3:95–105
Cinay GE, Erkoc P, Alipour M, Hashimoto Y, Sasaki Y, Akiyoshi K, Kizilel S (2017) ACS Biomater Sci Eng 3:370–380
Su X, Chan C, Shi J, Tsang M-K, Pan Y, Cheng C, Gerile O, Yang M (2017) Biosens Bioelectron 92:489–495
Javanbakht S, Shaabani A (2019) Int J Biol Macromol 123:389–397
Morimoto N, Endo T, Iwasaki Y, Akiyoshi K (2005) Biomacromol 6:1829–1834
Hennink WE, van Nostrum CF (2012) Adv Drug Delivery Rev 64:223–236
Ahmadi F, Oveisi Z, Samani SM, Amoozgar Z (2015) Res Pharm Sci 10:1
Sadeghi M, Hosseinzadeh H (2013) Braz J Chem Eng 30:379–389
Hajikarimi A, Sadeghi M (2020) J Polym Res 27:57
Nezami S, Sadeghi M (2020) Polym Bull 77:1255–1279
Hirakura T, Yasugi K, Nemoto T, Sato M, Shimoboji T, Aso Y, Morimoto N, Akiyoshi K (2010) J Controlled Release 142:483–489
Nematidil N, Sadeghi M, Nezami S, Sadeghi H (2019) Carbohydr Polym 222:114971
Abumanhal-Masarweh H, Koren L, Zinger A, Yaari Z, Krinsky N, Kaneti G, Dahan N, Lupu-Haber Y, Suss-Toby E, Weiss-Messer E (2019) J Controlled Release 296:1–13
Shagholani H, Ghoreishi SM (2017) J Drug Delivery Sci Technol 39:88–94
Qu J, Zhao X, Ma PX, Guo B (2017) Acta Biomater 58:168–180
Liu J, Stansbury JW (2014) Dent Mater 30:1252–1262
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The authors extend their appreciation to the Azad University of Arak-Iran for financial support of this work.
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Ghaem, B., Sadeghi, M. & Bardajee, G.R. Synthesis of Nano-Polymer Supported on Nano-Hydrogel Chitosan Base and Its Application for DOX Delivery. J Polym Environ 28, 2457–2468 (2020). https://doi.org/10.1007/s10924-020-01775-y
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DOI: https://doi.org/10.1007/s10924-020-01775-y