Abstract

Biogenic polyamines affect the properties of surface of Mycobacterium smegmatis cells. The presence of spermidine and spermine in the culture medium had a significant effect on the cell-surface charge and sliding motility of mycobacteria but did not affect the cell-surface hydrophobicity. Cell aggregation in M. smegmatis and the capacity for biofilm formation increased under polyamine treatment. Polyamines also decreased the antibiotic susceptibility of both planktonic forms and biofilms. For the first time, spermine has been shown to enhance the antimycobacterial activity of rifampicin, which is of interest for the treatment of mycobacterial infections.

中文翻译：

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生物多胺影响耻垢分枝杆菌的抗生素敏感性和细胞表面性质

摘要

生物多胺会影响耻垢分枝杆菌细胞表面的特性。培养基中亚精胺和亚精胺的存在对分枝杆菌的细胞表面电荷和滑动运动具有显着影响，但不影响细胞表面疏水性。在多胺处理下，耻垢分枝杆菌中的细胞聚集和生物膜形成的能力增加。多胺还降低了浮游形式和生物膜的抗生素敏感性。精胺首次显示出增强利福平的抗分枝杆菌活性，这对于治疗分枝杆菌感染很重要。