In particle therapy, the x-ray based treatment planning converting photon attenuation values to relative stopping power ratio (RSP) introduces clinically relevant range uncertainties. Recently, novel imaging technologies using transmission ion beams have been investigated to directly assess the water equivalent thickness (WET) of tissue, showing improved accuracy in RSP reconstruction, while potentially reducing the imaging dose. Due to their greater availability, protons have been mostly used for ion imaging. To this end, in this work, the influence of three ion species (protons, helium and carbon ions) on the image quality of radiographic WET retrieval has been explored with a dedicated experimental setup and compared to Monte Carlo (MC) simulations. Three phantom setups with different tissue interfaces and features have been irradiated with clinically validated proton, helium and carbon ion pencil beams under comparable imaging dose and beam settings at the Heidelberg Ion-Bea...

中文翻译：

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使用测距望远镜在成像应用中临床使用的离子束的实验比较。

在粒子疗法中，将光子衰减值转换为相对停止功率比（RSP）的基于X射线的治疗计划会引入临床上相关的范围不确定性。最近，已经研究了使用透射离子束的新颖成像技术，以直接评估组织的水当量厚度（WET），在RSP重建中显示出更高的准确性，同时有可能减少成像剂量。由于它们的可用性更高，因此质子已主要用于离子成像。为此，在这项工作中，使用专用的实验装置探索了三种离子种类（质子，氦和碳离子）对射线照相WET检索图像质量的影响，并将其与Monte Carlo（MC）模拟进行了比较。