Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy.,Lab on a Chip

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Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-07-27 , DOI: 10.1039/d0lc00458h
Jang Ho Ha ₁ , Ha Hee Shin , Hyung Woo Choi , Jae Hyun Lim , Sung Joon Mo , Christian D Ahrberg , Jong Min Lee , Bong Geun Chung

Affiliation

Electrical stimuli play an important role in regulating the delivery of plasmonic nanomaterials with cancer targeting peptides. Here, we developed an electro-responsive hydrogel-based microfluidic actuator platform for brain tumor targeting and photothermal therapy (PTT) applications. The electro-responsive hydrogels consisted of highly conductive silver nanowires (AgNWs) and biocompatible collagen I gels. We confirmed that an electrically conductive hydrogel could be used as an effective actuator by applying an electrical signal in the microfluidic platform. Furthermore, we successfully demonstrated PTT efficacy for brain tumor cells using targetable Arg-Gly-Asp (RGD) peptide-conjugated gold nanorods (GNRs). Therefore, our electro-responsive hydrogel-based microfluidic actuator platform could be useful for electro-responsive intelligent nanomaterial delivery and PTT applications.

中文翻译：

基于电响应水凝胶的微流致动器平台，用于光热疗法。

电刺激在调节具有癌症靶向肽的等离激元纳米材料的传递中起重要作用。在这里，我们为脑肿瘤靶向和光热疗法（PTT）应用开发了基于电响应水凝胶的微流致动器平台。电响应水凝胶由高导电性的银纳米线（AgNWs）和生物相容性胶原I凝胶组成。我们证实，通过在微流体平台中施加电信号，可以将导电水凝胶用作有效的致动器。此外，我们成功地证明了使用靶向Arg-Gly-Asp（RGD）肽缀合的金纳米棒（GNR）对脑肿瘤细胞的PTT功效。因此，

更新日期：2020-09-15

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