Issue 18, 2020
From the journal:

Lab on a Chip

Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy†

Jang Ho Ha,‡a   Ha Hee Shin,‡b   Hyung Woo Choi,a   Jae Hyun Lim,b   Sung Joon Mo,b   Christian D. Ahrberg,a   Jong Min Lee*ac  and  Bong Geun Chung ORCID logo *a  

* Corresponding authors

a Department of Mechanical Engineering, Sogang University, Seoul, Republic of Korea
E-mail: bchung@sogang.ac.kr

b Department of Biomedical Engineering, Sogang University, Seoul, Republic of Korea

c Division of Chemical Industry, Yeungnam University College, Daegu, Republic of Korea
E-mail: jlee@ync.ac.kr

Abstract

Electrical stimuli play an important role in regulating the delivery of plasmonic nanomaterials with cancer targeting peptides. Here, we developed an electro-responsive hydrogel-based microfluidic actuator platform for brain tumor targeting and photothermal therapy (PTT) applications. The electro-responsive hydrogels consisted of highly conductive silver nanowires (AgNWs) and biocompatible collagen I gels. We confirmed that an electrically conductive hydrogel could be used as an effective actuator by applying an electrical signal in the microfluidic platform. Furthermore, we successfully demonstrated PTT efficacy for brain tumor cells using targetable Arg-Gly-Asp (RGD) peptide-conjugated gold nanorods (GNRs). Therefore, our electro-responsive hydrogel-based microfluidic actuator platform could be useful for electro-responsive intelligent nanomaterial delivery and PTT applications.

Graphical abstract: Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0LC00458H
Article type
Paper
Submitted
06 May 2020
Accepted
25 Jul 2020
First published
27 Jul 2020

Lab Chip, 2020,20, 3354-3364

Permissions

Request permissions

Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy

J. H. Ha, H. H. Shin, H. W. Choi, J. H. Lim, S. J. Mo, C. D. Ahrberg, J. M. Lee and B. G. Chung, Lab Chip, 2020, 20, 3354 DOI: 10.1039/D0LC00458H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements