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Structure-Dependent Development of the Antihypoxic Activity of Benzothiazole Derivatives Under Hypoxic Conditions of Various Etiologies
Pharmaceutical Chemistry Journal ( IF 0.9 ) Pub Date : 2020-07-01 , DOI: 10.1007/s11094-020-02201-2
M. V. Troshina , O. A. Kh. Almukhtar , N. F. Petukhova , V. V. Yasnetsov , I. N. Krylova , E. G. Tsublova

The antihypoxic activities of new benzothiazole derivatives were studied in experiments on outbred male mice. The effects were found to be directly determined not only by the type of substituent on the heterocycle but also the organic acid in the molecule. The most pronounced effect was observed for molecules containing a succinate fragment.

中文翻译:

苯并噻唑衍生物在各种病因缺氧条件下抗缺氧活性的结构依赖性发展

在远交雄性小鼠的实验中研究了新的苯并噻唑衍生物的抗缺氧活性。发现这些影响不仅直接取决于杂环上的取代基类型,还取决于分子中的有机酸。对于含有琥珀酸片段的分子观察到最显着的效果。
更新日期:2020-07-01
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