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Structure-Dependent Development of the Antihypoxic Activity of Benzothiazole Derivatives Under Hypoxic Conditions of Various Etiologies

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Pharmaceutical Chemistry Journal Aims and scope

The antihypoxic activities of new benzothiazole derivatives were studied in experiments on outbred male mice. The effects were found to be directly determined not only by the type of substituent on the heterocycle but also the organic acid in the molecule. The most pronounced effect was observed for molecules containing a succinate fragment.

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Authors and Affiliations

  1. Bryansk State Academy of Engineering and Technological, Bryansk, 241037, Russia

    M. V. Troshina, O. A. Kh. Almukhtar, N. F. Petukhova & E. G. Tsublova

  2. Institute of Biomedical Problems, State Scientific Center of the Russian Federation, Russian Academy of Sciences, Moscow, 123007, Russia

    V. V. Yasnetsov

  3. I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia

    I. N. Krylova

Authors
  1. M. V. Troshina
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  2. O. A. Kh. Almukhtar
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  3. N. F. Petukhova
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  4. V. V. Yasnetsov
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  5. I. N. Krylova
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  6. E. G. Tsublova
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Corresponding author

Correspondence to M. V. Troshina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 4, pp. 16 – 10, April, 2020.

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Troshina, M.V., Almukhtar, O.A.K., Petukhova, N.F. et al. Structure-Dependent Development of the Antihypoxic Activity of Benzothiazole Derivatives Under Hypoxic Conditions of Various Etiologies. Pharm Chem J 54, 335–339 (2020). https://doi.org/10.1007/s11094-020-02201-2

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  • DOI: https://doi.org/10.1007/s11094-020-02201-2

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