Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells,Nanoscale Advances

当前位置： X-MOL 学术 › Nanoscale Adv. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells
Nanoscale Advances ( IF 4.6 ) Pub Date : 2020-07-23 , DOI: 10.1039/d0na00271b
Nerymar Ortiz-Otero ₁ , Jocelyn R Marshall ₁ , Bradley W Lash ₂ , Michael R King ₃

Affiliation

Several studies have demonstrated the role of platelets in promoting cancer metastasis. Platelets bind to and protect circulating tumor cells (CTCs) from hemodynamic forces and immune cells, and also promote tumor cell arrest in the vasculature and extravasation. Thus, platelets represent a promising vehicle to deliver anticancer therapeutic agents to CTCs. In this study, we developed a novel platelet-mediated TNF-related apoptosis inducing ligand (TRAIL) delivery system to target CTCs and hinder metastasis via “in situ” platelet modification. This platelet-mediated TRAIL delivery significantly reduced the viability of colorectal and breast cancer cells circulating in flowing blood under physiological shear conditions. TRAIL-coated platelets significantly killed over 60% of CTCs in flowing blood from a variety of primary metastatic cancer samples. Platelets have been considered an important player in the regulation of metastasis due to their interaction with cancer cells in the circulation; the current study supports the idea of using platelet-based TRAIL delivery as a promising CTC-targeted cancer therapy.

中文翻译：

血小板介导的 TRAIL 递送可有效靶向循环肿瘤细胞

一些研究已经证明了血小板在促进癌症转移中的作用。血小板与循环肿瘤细胞 (CTC) 结合并保护其免受血液动力学和免疫细胞的影响，同时促进肿瘤细胞在脉管系统中的停滞和外渗。因此，血小板代表了将抗癌治疗剂递送至 CTC 的有希望的载体。在这项研究中，我们开发了一种新型血小板介导的 TNF 相关凋亡诱导配体 (TRAIL) 递送系统，以靶向 CTC 并通过“原位”阻止转移。” 血小板修饰。这种血小板介导的 TRAIL 递送显着降低了在生理剪切条件下在流动血液中循环的结肠直肠癌细胞和乳腺癌细胞的活力。TRAIL 涂层的血小板显着杀死了来自各种原发性转移性癌症样本的流动血液中超过 60% 的 CTC。血小板被认为是调节转移的重要参与者，因为它们与循环中的癌细胞相互作用；目前的研究支持使用基于血小板的 TRAIL 递送作为有前途的 CTC 靶向癌症治疗的想法。

更新日期：2020-09-16

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文