Issue 9, 2020
From the journal:

Nanoscale Advances

Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells†

Nerymar Ortiz-Otero,a   Jocelyn R. Marshall,a   Bradley W. Lashb  and  Michael R. King ORCID logo *c  

* Corresponding authors

a Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA
E-mail: mike.king@vanderbilt.edu

b Lehigh Valley Health Network, Allentown, PA 18103, USA

c Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37202, USA

Abstract

Several studies have demonstrated the role of platelets in promoting cancer metastasis. Platelets bind to and protect circulating tumor cells (CTCs) from hemodynamic forces and immune cells, and also promote tumor cell arrest in the vasculature and extravasation. Thus, platelets represent a promising vehicle to deliver anticancer therapeutic agents to CTCs. In this study, we developed a novel platelet-mediated TNF-related apoptosis inducing ligand (TRAIL) delivery system to target CTCs and hinder metastasis via “in situ” platelet modification. This platelet-mediated TRAIL delivery significantly reduced the viability of colorectal and breast cancer cells circulating in flowing blood under physiological shear conditions. TRAIL-coated platelets significantly killed over 60% of CTCs in flowing blood from a variety of primary metastatic cancer samples. Platelets have been considered an important player in the regulation of metastasis due to their interaction with cancer cells in the circulation; the current study supports the idea of using platelet-based TRAIL delivery as a promising CTC-targeted cancer therapy.

Graphical abstract: Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells

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Article information

DOI
https://doi.org/10.1039/D0NA00271B
Article type
Paper
Submitted
05 Apr 2020
Accepted
22 Jul 2020
First published
23 Jul 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 3942-3953

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Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells

N. Ortiz-Otero, J. R. Marshall, B. W. Lash and M. R. King, Nanoscale Adv., 2020, 2, 3942 DOI: 10.1039/D0NA00271B

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