The search for new herbal-based immune-pharmacological agents for the treatment of several infectious diseases caused by fungi, bacteria, and protozoa, such as leishmaniasis, has led to the investigation of natural products and their main components from different plants species. Currently available antileishmanial drugs are limited, and resistance is common in clinical field isolates. So there is an urgent need to develop herbal-based antileishmanial agent. In our study, the potential of essential oil (EO) isolated from Agrimonia pilosa Ledeb has been investigated against Leishmania donovani, the causative agent of visceral leishmaniasis. The EO was safer on the J774.A1 macrophages and fatal to both promastigotes and intracellular amastigotes forms at different concentrations (10, 50 and 100 µg/ml). Thus, in search of herbal medicine for visceral leishmaniasis, A. pilosa may provide new lead molecules in the form of EO.

寻找用于治疗由真菌，细菌和原生动物引起的几种传染病（例如利什曼病）的新的基于草药的免疫药理剂，已导致人们研究了天然产物及其来自不同植物物种的主要成分。当前可用的抗衰老药物有限，并且耐药性在临床领域分离株中很常见。因此，迫切需要开发基于草药的除臭剂。在我们的研究中，已经研究了从香龙草中提取的精油（EO）对利什曼原虫多诺万尼的潜力。，内脏利什曼病的病原体。EO在J774.A1巨噬细胞上更安全，并且对不同浓度（10、50和100 µg / ml）的前鞭毛体和胞内变形虫均致命。因此，为了寻找用于内脏利什曼病的草药，A。pilosa可能以EO的形式提供新的先导分子。