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In Vitro Antileishmanial Activity of the Essential Oil from Agrimonia pilosa

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Abstract

The search for new herbal-based immune-pharmacological agents for the treatment of several infectious diseases caused by fungi, bacteria, and protozoa, such as leishmaniasis, has led to the investigation of natural products and their main components from different plants species. Currently available antileishmanial drugs are limited, and resistance is common in clinical field isolates. So there is an urgent need to develop herbal-based antileishmanial agent. In our study, the potential of essential oil (EO) isolated from Agrimonia pilosa Ledeb has been investigated against Leishmania donovani, the causative agent of visceral leishmaniasis. The EO was safer on the J774.A1 macrophages and fatal to both promastigotes and intracellular amastigotes forms at different concentrations (10, 50 and 100 µg/ml). Thus, in search of herbal medicine for visceral leishmaniasis, A. pilosa may provide new lead molecules in the form of EO.

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Acknowledgments

Authors are thankful to Department of Zoology and Department of Chemistry, Kumaun University SSJ campus, Almora (Uttarakhand), India, for providing the facility for this work. This study was financially supported by the Science and Engineering Research Board (SERB, India) young scientist GRANT YSS/2014/000773 awarded to MS.

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Author notes

  1. Devendra Singh Dhami and Satish Chandra Pandey have contributed equally to this study.

Authors and Affiliations

  1. Department of Chemistry, Kumaun University, SSJ Campus, Almora, Uttarakhand, India

    Devendra Singh Dhami, Girish Chandra Shah & Manisha Bisht

  2. Cell and Molecular Biology Laboratory, Department of Zoology, Kumaun University, SSJ Campus, Almora, Uttarakhand, 263601, India

    Satish Chandra Pandey & Mukesh Samant

  3. Department of Biotechnology, Kumaun University, Bhimtal Campus, Nainital, Uttarakhand, India

    Satish Chandra Pandey

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  1. Devendra Singh Dhami
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Correspondence to Mukesh Samant.

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Dhami, D.S., Pandey, S.C., Shah, G.C. et al. In Vitro Antileishmanial Activity of the Essential Oil from Agrimonia pilosa. Natl. Acad. Sci. Lett. 44, 195–198 (2021). https://doi.org/10.1007/s40009-020-00992-2

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  • DOI: https://doi.org/10.1007/s40009-020-00992-2

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