当前位置:
X-MOL 学术
›
Environ. Sci. Eur.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
PM 2.5 exposure induced renal injury via the activation of the autophagic pathway in the rat and HK-2 cell
Environmental Sciences Europe ( IF 6.0 ) Pub Date : 2020-07-16 , DOI: 10.1186/s12302-020-00378-7 Xiaoliu Huang , Zhitong Zhou , Xinwen Liu , Jue Li , Lijuan Zhang
中文翻译:
PM 2.5暴露通过激活大鼠和HK-2细胞的自噬途径而引起肾损伤
更新日期:2020-07-16
Environmental Sciences Europe ( IF 6.0 ) Pub Date : 2020-07-16 , DOI: 10.1186/s12302-020-00378-7 Xiaoliu Huang , Zhitong Zhou , Xinwen Liu , Jue Li , Lijuan Zhang
Background
Exposure to airborne fine particulate matter (PM2.5) has been declared to be harmful to human kidney. However, whether activation of the autophagic pathway plays key roles in the nephrotoxicity caused by PM2.5 exposure is still poorly understood. The aim of this study was to explore the mechanism of kidney damage after PM2.5 exposure in vivo and in vitro.Results
In the present study, statistically significant alterations in water intake, urine flow rate and mean blood pressure were observed between the concentrated PM2.5 (PM2.5) group and the filtered air (FA) group. Exposed animals showed severe edema of renal tubular epithelial cells, capillary congestion, reduction of the glomerular urinary space and early pro-fibrotic state. Moreover, significant increases in the levels of early kidney damage markers were observed in the exposed rats and these animals exhibited more apoptosis rate in kidney cells. In addition, PM2.5 exposure activated the autophagic pathway, as evidenced by LC3-I to LC3-II conversion, activation of P62 and beclin-1. All of these effects are in concurrence with the presence of more autophagosomes both in vivo and in vitro after PM2.5 exposure.Conclusions
Taken together, our findings indicated that PM2.5 induced renal function impairment via the activation of the autophagic pathway in renal tubular epithelial cells.中文翻译:
PM 2.5暴露通过激活大鼠和HK-2细胞的自噬途径而引起肾损伤