Abstract

A 3D neutral porous MOF (1), [Co₂(tdc)₂(Hdatz)·DMF(H₂O)₃]_n (H₂tdc = 2,5-thiophenedicarboxylic acid, Hdatz = 3,5-diamino-1,2,4-triazole), which has aplenty micropores along with free groups of NH₂ was assembled via combining 2,5-thiophenedicarboxylic acid ligands and nitrogen-rich 3,5-diamino-1,2,4-triazole as well as Co(II) ion. The activated MOF (1a) has a fine affinity for CO₂ molecules and a fine catalytic performance for the conversion of CO₂ with internal epoxides along with various terminal ones. Furthermore, the protective activity of 1a on acute heart failure was evaluated by measuring left ventricular ejection fraction and Left ventricular fraction shortening. And the mechanism of this compound was explored by detect the Hif-1α expression level.

Graphic abstract

Synopsis A 3D neutral porous MOF based on 2,5-thiophenedicarboxylic acid and 3,5-diamino-1,2,4-triazole as the organic linkers has been prepared, which has microporous network decorate with free NH₂ groups. The activated MOF has a fine affinity for CO₂ molecules and a fine catalytic performance for the conversion of CO₂ with internal epoxides along with various terminal ones. Furthermore, the protective activity of 1a on acute heart failure was evaluated by measuring LVEF and LVFS. And the mechanism of this compound was explored by detect the Hif-1α expression level.

中文翻译：

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具有富氮微孔的健壮Co（II）-MOF，用于CO 2转化和通过增加Hif-1α的表达对急性心力衰竭的保护作用

摘要

3D中性多孔MOF（1），[Co ₂（tdc）₂（Hdatz）·DMF（H ₂ O）₃ ] _n（H ₂ tdc = 2,5-噻吩二甲酸，Hdatz = 3,5-二氨基-1通过结合2,5-噻吩二羧酸配体和富氮3,5-二氨基-1,2,4-三唑以及具有大量NH ₂游离基的2,4-三唑）钴（II）离子。活化的MOF（1a）对CO ₂分子具有良好的亲和力，并且对于内部环氧化物与各种末端环氧化物一起转化CO ₂具有良好的催化性能。此外，对通过测量左心室射血分数和缩短左心室分数来评估1a对急性心力衰竭的影响。通过检测Hif-1α的表达水平探讨了该化合物的作用机理。

图形摘要

概述已制备了基于2,5-噻吩二甲酸和3,5-二氨基-1,2,4-三唑作为有机连接基的3D中性多孔MOF，其具有由游离NH ₂基修饰的微孔网络。活化的MOF对CO ₂分子具有良好的亲和力，并且对于具有内部环氧化物以及各种末端化合物的CO ₂转化具有良好的催化性能。此外，通过测量LVEF和LVFS评估了1a对急性心力衰竭的保护活性。通过检测Hif-1α的表达水平探讨了该化合物的作用机理。