Abstract
A 3D neutral porous MOF (1), [Co2(tdc)2(Hdatz)·DMF(H2O)3]n (H2tdc = 2,5-thiophenedicarboxylic acid, Hdatz = 3,5-diamino-1,2,4-triazole), which has aplenty micropores along with free groups of NH2 was assembled via combining 2,5-thiophenedicarboxylic acid ligands and nitrogen-rich 3,5-diamino-1,2,4-triazole as well as Co(II) ion. The activated MOF (1a) has a fine affinity for CO2 molecules and a fine catalytic performance for the conversion of CO2 with internal epoxides along with various terminal ones. Furthermore, the protective activity of 1a on acute heart failure was evaluated by measuring left ventricular ejection fraction and Left ventricular fraction shortening. And the mechanism of this compound was explored by detect the Hif-1α expression level.
Graphic abstract
Synopsis A 3D neutral porous MOF based on 2,5-thiophenedicarboxylic acid and 3,5-diamino-1,2,4-triazole as the organic linkers has been prepared, which has microporous network decorate with free NH2 groups. The activated MOF has a fine affinity for CO2 molecules and a fine catalytic performance for the conversion of CO2 with internal epoxides along with various terminal ones. Furthermore, the protective activity of 1a on acute heart failure was evaluated by measuring LVEF and LVFS. And the mechanism of this compound was explored by detect the Hif-1α expression level.
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Song, W., Song, S., Feng, X. et al. A robust Co(II)-MOF with nitrogen-rich micropores for CO2 transformation and protective effect on acute heart failure treatment by increasing the expression of Hif-1α. J Chem Sci 132, 85 (2020). https://doi.org/10.1007/s12039-020-01788-z
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DOI: https://doi.org/10.1007/s12039-020-01788-z