Au nanocone array with 3D hotspots for biomarker chips,CrystEngComm

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Au nanocone array with 3D hotspots for biomarker chips
CrystEngComm ( IF 2.6 ) Pub Date : 2020-07-08 , DOI: 10.1039/d0ce00786b
Qi Zhu _{1,

2,

3,

4,

5} , Xiaoyu Zhao _{6,

7,

8,

9} , Xiaolong Zhang _{1,

2,

3,

4,

5} , Aonan Zhu _{1,

2,

3,

4,

5} , Renxian Gao _{1,

2,

3,

4,

5} , Yongjun Zhang _{6,

7,

8,

9} , Yaxin Wang _{6,

7,

8,

9} , Lei Chen _{4,

9,

10,

11}

Affiliation

AFP-L3 is one of the most important biomarkers for the early diagnosis of liver cancer. Surface-enhanced Raman scattering is a suitable tool for AFP-L3 detection thanks to its high-sensitivity analytical ability with the fingerprint effect. Here, nanocone arrays were prepared as SERS-active substrate based on nanosphere lithography. When controlling the deposition angle, the period of the patterned array, and the growth time, the distances between adjacent Au nanocones were reduced and the sharpness of the tips was changed so as to provide a significant SERS signal as 3D hotspots. The changes of the incident angle of the light source increased the number of hotspots to provide more significant SERS signals. Based on the peak shift analysis of the characteristic peaks of the probe molecule 4-MBA, AFP-L3 could be detected at a concentration down to 0.5 ng ml⁻¹.

中文翻译：

具有3D热点的金纳米锥阵列用于生物标记芯片

AFP-L3是肝癌早期诊断的最重要的生物标志物之一。表面增强拉曼散射由于具有指纹效应的高灵敏度分析能力，因此是检测AFP-L3的合适工具。在这里，纳米球阵列被制备为基于纳米球光刻的SERS活性衬底。当控制沉积角度，图案阵列的周期和生长时间时，相邻Au纳米锥之间的距离减小，尖端的锐度改变，从而提供了明显的SERS信号作为3D热点。光源的入射角的变化增加了热点的数量，以提供更重要的SERS信号。根据探针4-MBA的特征峰的峰移分析，^-1。

更新日期：2020-08-10

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