Au nanocone array with 3D hotspots for biomarker chips

Qi Zhu; Xiaoyu Zhao; Xiaolong Zhang; Aonan Zhu; Renxian Gao; Yongjun Zhang; Yaxin Wang; Lei Chen

doi:10.1039/D0CE00786B

Au nanocone array with 3D hotspots for biomarker chips†

Qi Zhu,‡^a Xiaoyu Zhao,‡^b Xiaolong Zhang,

*^a Aonan Zhu,

^a Renxian Gao,^a Yongjun Zhang,^b Yaxin Wang*^b and Lei Chen^c

Author affiliations

* Corresponding authors

^a Key Laboratory of Functional Materials Physics and Chemistry, Ministry of Education, College of Physics, Jilin Normal University, Changchun 130103, P.R.China
E-mail: zhangxiaolong@jlnu.edu.cn

^b School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310012, P.R. China
E-mail: yaxinwang@hdu.edu.cn

^c College of Chemistry, Jilin Normal University, Siping, P.R. China

Abstract

AFP-L3 is one of the most important biomarkers for the early diagnosis of liver cancer. Surface-enhanced Raman scattering is a suitable tool for AFP-L3 detection thanks to its high-sensitivity analytical ability with the fingerprint effect. Here, nanocone arrays were prepared as SERS-active substrate based on nanosphere lithography. When controlling the deposition angle, the period of the patterned array, and the growth time, the distances between adjacent Au nanocones were reduced and the sharpness of the tips was changed so as to provide a significant SERS signal as 3D hotspots. The changes of the incident angle of the light source increased the number of hotspots to provide more significant SERS signals. Based on the peak shift analysis of the characteristic peaks of the probe molecule 4-MBA, AFP-L3 could be detected at a concentration down to 0.5 ng ml⁻¹.

Supplementary files

Article information

DOI: https://doi.org/10.1039/D0CE00786B
Article type: Paper
Submitted: 30 May 2020
Accepted: 06 Jul 2020
First published: 08 Jul 2020

Download Citation

CrystEngComm, 2020,22, 5191-5199

Permissions

Request permissions

Au nanocone array with 3D hotspots for biomarker chips

Q. Zhu, X. Zhao, X. Zhang, A. Zhu, R. Gao, Y. Zhang, Y. Wang and L. Chen, CrystEngComm, 2020, 22, 5191 DOI: 10.1039/D0CE00786B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

CrystEngComm

Au nanocone array with 3D hotspots for biomarker chips†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Au nanocone array with 3D hotspots for biomarker chips

Social activity

Search articles by author

Spotlight

Advertisements