Abstract

Simulation of the behavior of stenosis arteries has received much attention as a research topic. Fluid mechanics of blood flow in the left coronary artery (LCA) with stenosis is studied using a mathematical analysis. Numerical simulations of blood flow in the left coronary artery with different stenosis percentages were performed. Both Newtonian and non-Newtonian models were considered for blood. The flow was assumed to be pulsatile and laminar. Stenotic human coronary artery geometries were given based on the images obtained from real patients (coronarography). The coupled governing equations, continuity and momentum were non-dimensionalized and solved. The effect of stenosis on various physiologically important flow variables during the cardiac cycle including pressure drop, impedance, velocity profile, and wall shear stress (WSS) was studied. It is found that all these flow parameters remarkably vary across a stenotic lesion. Also, an increase in the stenosis percentage leads to a considerable increase in their magnitudes.

中文翻译：

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狭窄的左冠状弯曲动脉的稳态和生理逼真的脉动血流的三维数值研究

摘要

狭窄动脉行为的模拟已作为研究课题受到广泛关注。使用数学分析研究了狭窄的左冠状动脉（LCA）中血液流动的流体力学。进行了不同狭窄百分比的左冠状动脉血流的数值模拟。牛顿模型和非牛顿模型都考虑了血液。假定流动是脉动的和层流的。根据从真实患者（冠状动脉造影）获得的图像给出狭窄的人冠状动脉几何形状。耦合的控制方程，连续性和动量未进行量纲化和求解。研究了狭窄对心动周期中各种重要生理流量变量的影响，包括压力下降，阻抗，速度分布和壁切应力（WSS）。发现所有这些流量参数在整个狭窄病变处均显着变化。同样，狭窄百分比的增加导致其幅度的显着增加。