Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway.,Food & Function

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Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway.
Food & Function ( IF 5.1 ) Pub Date : 2020-07-06 , DOI: 10.1039/d0fo00235f
M L Castejón ₁ , T Montoya ₁ , C Alarcón-de-la-Lastra ₁ , A González-Benjumea ₂ , M V Vázquez-Román ₃ , M Sánchez-Hidalgo ₁

Affiliation

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment. Besides, macrophages are the major components of the innate immune system and play a critical role in the inflammation process in SLE. Secoiridoids from olive tree are phenolic compounds which have shown important pharmacological effects. Particularly, oleuropein (OL) has shown antioxidant, anti-inflammatory and immunomodulatory properties suggesting a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. In addition, different studies have shown the importance of acyl derivatives of natural phenols due to their better hydrophilic/lipophilic balance.

中文翻译：

日粮橄榄苦苷及其酰基衍生物通过标准的和非经典的NLRP3炎症小体途径改善了p烷诱导的SLE小鼠腹膜巨噬细胞的炎症反应。

系统性红斑狼疮（SLE）是一种多因素自身免疫性疾病，没有有效而安全的治疗方法。此外，巨噬细胞是先天免疫系统的主要组成部分，并在SLE的炎症过程中起关键作用。橄榄树中的类胡萝卜素是酚类化合物，已显示出重要的药理作用。特别地，橄榄苦苷（OL）已显示出抗氧化，抗炎和免疫调节特性，表明在许多炎症和活性氧（ROS）介导的疾病中有潜在的应用。此外，不同的研究表明天然酚的酰基衍生物具有更好的亲水性/亲脂性平衡，因此很重要。

更新日期：2020-07-22

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