Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway

M. L. Castejón; T. Montoya; C. Alarcón-de-la-Lastra; A. González-Benjumea; M. V. Vázquez-Román; M. Sánchez-Hidalgo

doi:10.1039/D0FO00235F

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Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway

M. L. Castejón,

^a T. Montoya,^a C. Alarcón-de-la-Lastra,^a A. González-Benjumea,^b M. V. Vázquez-Román^c and M. Sánchez-Hidalgo*^a

Author affiliations

* Corresponding authors

^a Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
E-mail: hidalgosanz@us.es
Fax: +34954556074
Tel: +34954557489

^b Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville, Spain

^c Department of Normal and Pathological Cytology and Histology, Faculty of Medicine, University of Seville, Seville, Spain

Abstract

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment. Besides, macrophages are the major components of the innate immune system and play a critical role in the inflammation process in SLE. Secoiridoids from olive tree are phenolic compounds which have shown important pharmacological effects. Particularly, oleuropein (OL) has shown antioxidant, anti-inflammatory and immunomodulatory properties suggesting a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. In addition, different studies have shown the importance of acyl derivatives of natural phenols due to their better hydrophilic/lipophilic balance.

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DOI: https://doi.org/10.1039/D0FO00235F
Article type: Paper
Submitted: 27 Jan 2020
Accepted: 12 Jun 2020
First published: 06 Jul 2020

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Food Funct., 2020,11, 6622-6631

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Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway

M. L. Castejón, T. Montoya, C. Alarcón-de-la-Lastra, A. González-Benjumea, M. V. Vázquez-Román and M. Sánchez-Hidalgo, Food Funct., 2020, 11, 6622 DOI: 10.1039/D0FO00235F

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Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway

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Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway

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