CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.

中文翻译：

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CAR T细胞经过改造，可以识别肿瘤特异性抗原并杀死肿瘤细胞。使用单分子显微镜对CAR T细胞活化进行的研究表明，CAR无法有效地将抗原结合转化为早期T细胞信号转导事件。