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CARs need a jump start to get going.
Nature Immunology ( IF 27.7 ) Pub Date : 2020-07-06 , DOI: 10.1038/s41590-020-0735-0
Björn F Lillemeier 1
Affiliation  

CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.

中文翻译:

汽车需要快速启动才能开始。

CAR T细胞经过改造,可以识别肿瘤特异性抗原并杀死肿瘤细胞。使用单分子显微镜对CAR T细胞活化进行的研究表明,CAR无法有效地将抗原结合转化为早期T细胞信号转导事件。
更新日期:2020-07-06
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