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CAR T CELLS

CARs need a jump start to get going

Nature Immunology volume 21, pages 823–824 (2020)Cite this article

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CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.

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Fig. 1: CAR T cells are less efficient than conventional T cells at converting antigen binding into early T cell–signaling events.

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Authors and Affiliations

  1. Nomis Center for Immunobiology and Microbial Pathogenesis & Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA, USA

    Björn F. Lillemeier

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  1. Björn F. Lillemeier
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Correspondence to Björn F. Lillemeier.

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The author declares there is no competing interest.

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Lillemeier, B.F. CARs need a jump start to get going. Nat Immunol 21, 823–824 (2020). https://doi.org/10.1038/s41590-020-0735-0

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