In this research study, the effect of zirconia nanoparticles on the biological properties of the hydroxyapatite (HA) scaffolds was evaluated. The zirconia nanoparticles with various weight percentages of 5, 10, and 20 were mixed with hydroxyapatite powder using a ball-milling process. Then, they were cold pressed and heat-treated at 1150 °C. Scanning electron microscope and x-ray diffraction analysis were used to evaluate the morphology and phase analysis of the samples, respectively. The results of the microstructure and phase analysis revealed that some zirconia nanoparticles reacted with the HA during the sintering process, which besides the formation of the tertiary calcium phosphate and calcium zirconium phases, it resulted in creating some microporosities in the scaffold. The biological behavior of the samples was investigated by osteoblast-like cells. The results of the biological assessment demonstrated that the presence of the zirconia nanoparticles in the HA scaffold improved the biological behavior (cell attachment and cell proliferation). The HA specimen composed with 10 wt.% zirconia nanoparticles showed the highest bioactivity. In addition, the compressive strength of the HA sample composed of 10 wt.% zirconia nanoparticles was improved by 30%.

在这项研究中，评估了氧化锆纳米粒子对羟基磷灰石（HA）支架生物学特性的影响。使用球磨工艺将各种重量百分比分别为5、10和20的氧化锆纳米粒子与羟基磷灰石粉末混合。然后，将它们冷压并在1150°C下进行热处理。扫描电子显微镜和X射线衍射分析分别用于评估样品的形态和相分析。微观结构和相分析的结果表明，在烧结过程中，一些氧化锆纳米粒子与HA反应，这不仅形成了叔磷酸钙和钙锆相，还导致了支架中产生一些微孔。通过成骨细胞样细胞研究样品的生物学行为。生物学评估的结果表明，HA支架中氧化锆纳米粒子的存在改善了生物学行为（细胞附着和细胞增殖）。由10重量％氧化锆纳米粒子组成的HA标本显示出最高的生物活性。另外，由10重量％的氧化锆纳米颗粒组成的HA样品的抗压强度提高了30％。