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Antagonists D1 and D2 of Dopamine Receptors Determine Different Mechanisms of Neuroprotective Action in the Frog Vestibular.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920030084 I V Ryzhova 1 , T V Tobias 1 , A D Nozdrachev 1
中文翻译:
多巴胺受体拮抗剂D1和D2确定了青蛙前庭神经保护作用的不同机制。
更新日期:2020-07-06
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920030084 I V Ryzhova 1 , T V Tobias 1 , A D Nozdrachev 1
Affiliation
Abstract
The high functional plasticity of the glutamatergic synapse of the vestibular epithelium is supported by a delicate balance of excitatory and inhibitory interactions. One of the peptides co-localized with acetylcholine (ACh) in the efferent fibers is dopamine. Using external perfusion of the synaptic zone and multiunit recording of an afferent fibers activity the effect of dopamine antagonists on the background firing rate of the semicircular canal sensory fibers was studied on the isolated frog vestibular. The present research revealed that the dopamine receptor antagonist (D1) SCH-23390 significantly reduced the level of background activity at high concentrations. In contrast, D2 antagonist eticlopride caused positive-negative answer of the background activity of the sensory fibers in dose-depending manner. The data confirm the hypothesis that dopamine, being tonic released from the efferent fibers, realizes neuroprotective inhibitory control over the afferent glutamatergic synapse activity in the vestibular epithelium via D1 and D2 receptors.中文翻译:
多巴胺受体拮抗剂D1和D2确定了青蛙前庭神经保护作用的不同机制。