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Epitope Analysis of Murine and Chimeric Monoclonal Antibodies Recognizing the Cancer Testis Antigen PRAME.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920030072 V A Misyurin 1 , Yu P Finashutina 1 , A A Turba 2 , M V Larina 1 , O N Solopova 1 , N A Lyzhko 1 , L A Kesaeva 1 , N N Kasatkina 1 , T K Aliev 1, 3 , A V Misyurin 2 , M P Kirpichnikov 3, 4
中文翻译：
识别癌症睾丸抗原PRAME的鼠和嵌合单克隆抗体的表位分析。
更新日期：2020-07-06
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920030072 V A Misyurin 1 , Yu P Finashutina 1 , A A Turba 2 , M V Larina 1 , O N Solopova 1 , N A Lyzhko 1 , L A Kesaeva 1 , N N Kasatkina 1 , T K Aliev 1, 3 , A V Misyurin 2 , M P Kirpichnikov 3, 4
Affiliation
Abstract
We investigated the epitope specificity of different monoclonal antibodies recognizing the cancer testis antigen PRAME. Antibody 5D3 binds to the fragment of PRAME corresponding to 160–180 amino acid residues. Antibodies 6H8 and F11 bind to the fragment corresponding to 180–200 amino acid residues of PRAME. These antibodies retained the ability to recognize these PRAME fragments after chimerization.中文翻译：
识别癌症睾丸抗原PRAME的鼠和嵌合单克隆抗体的表位分析。
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