Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia–reperfusion injury (MIRI). However, no effective treatment is currently available for MIRI. To improve the prognosis of people with cardiovascular disease, it is important to research the mechanism of MIRI. Arachidonic acid (AA) is one of the focuses of current research. The various metabolic pathways of AA are closely related to the development of cardiovascular disease, and the roles of various metabolites in ischemia–reperfusion injury have gradually been confirmed. AA is mainly metabolized in the cyclooxygenase (COX) pathway, lipoxygenase (LOX) pathway, and cytochrome P450 monooxygenase (CYP) pathway. This paper summarizes the progress of research on these three major AA metabolic pathways with respect to MIRI.

中文翻译：

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花生四烯酸代谢在心肌缺血再灌注损伤中的作用。

患有心肌缺血性疾病或正在接受心脏直视手术、冠状动脉旁路移植术、经皮冠状动脉介入治疗或药物溶栓等各种心脏治疗之一的患者面临心肌缺血再灌注损伤 (MIRI)。然而，目前对于 MIRI 尚无有效的治疗方法。为了改善心血管疾病患者的预后，研究MIRI的机制具有重要意义。花生四烯酸(AA)是当前研究的热点之一。AA的多种代谢途径与心血管疾病的发生发展密切相关，各种代谢产物在缺血再灌注损伤中的作用逐渐得到证实。AA主要通过环氧合酶（COX）途径、脂氧合酶（LOX）途径和细胞色素P450单加氧酶（CYP）途径代谢。