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The Role of Arachidonic Acid Metabolism in Myocardial Ischemia–Reperfusion Injury

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Abstract

Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia–reperfusion injury (MIRI). However, no effective treatment is currently available for MIRI. To improve the prognosis of people with cardiovascular disease, it is important to research the mechanism of MIRI. Arachidonic acid (AA) is one of the focuses of current research. The various metabolic pathways of AA are closely related to the development of cardiovascular disease, and the roles of various metabolites in ischemia–reperfusion injury have gradually been confirmed. AA is mainly metabolized in the cyclooxygenase (COX) pathway, lipoxygenase (LOX) pathway, and cytochrome P450 monooxygenase (CYP) pathway. This paper summarizes the progress of research on these three major AA metabolic pathways with respect to MIRI.

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Author Contributions

H.X., Y.H.L., and Y.Z.D. contributed to the conception of the study. C.J.Z., M.L.H., L.H.N., K.H., and K.S. contributed significantly to analysis and paper preparation. All authors read and approved the final paper.

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Author notes

  1. These authors contributed equally: Changjiang Zhang, Meiling He, Lihua Ni, Ke He, Ke Su

Authors and Affiliations

  1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, PR China

    Changjiang Zhang & Hao Xia

  2. Cardiovascular Research Institute, Wuhan University, Wuhan, 430060, PR China

    Changjiang Zhang & Hao Xia

  3. Hubei Key Laboratory of Cardiology, Wuhan, 430060, PR China

    Changjiang Zhang

  4. Department of Medicine, Wuhan University, Wuhan, 420100, PR China

    Meiling He

  5. Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China

    Lihua Ni

  6. Department of Cardiology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, PR China

    Ke He, Ke Su & Yuanhong Li

  7. Department of Digestive Medicine, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, PR China

    Yinzhi Deng

  8. Institute of Cardiovascular Diseases, Wuhan University, Wuhan, 430060, PR China

    Hao Xia

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  1. Changjiang Zhang
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Correspondence to Yinzhi Deng, Yuanhong Li or Hao Xia.

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Zhang, C., He, M., Ni, L. et al. The Role of Arachidonic Acid Metabolism in Myocardial Ischemia–Reperfusion Injury. Cell Biochem Biophys 78, 255–265 (2020). https://doi.org/10.1007/s12013-020-00928-z

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  • DOI: https://doi.org/10.1007/s12013-020-00928-z

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