Backgound

Central obesity in midlife is a risk factor of cognitive decline and dementia, and also one of the factors that make cognitive functions deteriorate rapidly.

Objective

The objective of this study is to investigate the relationship between truncal body composition (fat and muscle) and cognitive impairment in patients with dementia.

Methods

A total of 81 female over 60 years of age with probable Alzheimer’s disease were recruited between November 2014 and September 2015. The Mini-Mental State Examination, Global Deterioration Scale, and Clinical Dementia Rating Scale were used to assess the cognitive functions. Both truncal fat and muscle mass were measured using body dual-energy X-ray absorptiometry and used as a percentage of body weight (TMM% and TFM%). Correlations between truncal composition and cognitive status were assessed by simple correlation analysis, which was followed by partial correlation analysis with age and educational years.

Results

TFM% was not related to cognitive impairment. In contrast, TMM% had a significantly negative correlation with all three cognitive assessment scores. After further adjusting for age, educational years, and vascular factors, there was still a relationship between TMM% and cognitive functions.

Conclusions

Unlike truncal fat mass that showed no relevance with cognitive functions, the truncal muscle mass was negatively correlated with cognitive status. The truncal muscle mass is thought to affect cognitive status in dementia patients somehow.

中文翻译：

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痴呆患者躯干身体成分与认知状态的关联。

背景

中年向心性肥胖是认知能力下降和痴呆的危险因素，也是使认知功能迅速恶化的因素之一。

客观的

本研究的目的是调查痴呆患者躯干身体成分（脂肪和肌肉）与认知障碍之间的关系。

方法

2014 年 11 月至 2015 年 9 月期间，共招募了 81 名 60 岁以上可能患有阿尔茨海默病的女性。使用简易精神状态检查、全球恶化量表和临床痴呆评定量表评估认知功能。使用身体双能 X 射线吸收法测量躯干脂肪和肌肉质量，并用作体重百分比（TMM% 和 TFM%）。通过简单相关分析评估躯干成分与认知状态之间的相关性，然后进行年龄和教育年限的偏相关分析。

结果

TFM% 与认知障碍无关。相比之下，TMM% 与所有三个认知评估分数呈显着负相关。在进一步调整年龄、受教育年限和血管因素后，TMM% 与认知功能之间仍有关系。

结论

与与认知功能无关的躯干脂肪量不同，躯干肌肉量与认知状态呈负相关。躯干肌肉质量被认为会以某种方式影响痴呆患者的认知状态。