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Associations of truncal body composition with cognitive status in patients with dementia

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Abstract

Backgound

Central obesity in midlife is a risk factor of cognitive decline and dementia, and also one of the factors that make cognitive functions deteriorate rapidly.

Objective

The objective of this study is to investigate the relationship between truncal body composition (fat and muscle) and cognitive impairment in patients with dementia.

Methods

A total of 81 female over 60 years of age with probable Alzheimer’s disease were recruited between November 2014 and September 2015. The Mini-Mental State Examination, Global Deterioration Scale, and Clinical Dementia Rating Scale were used to assess the cognitive functions. Both truncal fat and muscle mass were measured using body dual-energy X-ray absorptiometry and used as a percentage of body weight (TMM% and TFM%). Correlations between truncal composition and cognitive status were assessed by simple correlation analysis, which was followed by partial correlation analysis with age and educational years.

Results

TFM% was not related to cognitive impairment. In contrast, TMM% had a significantly negative correlation with all three cognitive assessment scores. After further adjusting for age, educational years, and vascular factors, there was still a relationship between TMM% and cognitive functions.

Conclusions

Unlike truncal fat mass that showed no relevance with cognitive functions, the truncal muscle mass was negatively correlated with cognitive status. The truncal muscle mass is thought to affect cognitive status in dementia patients somehow.

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Funding

This research was supported by the Brain Research Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2018M3C7A1056571).

Author information

Authors and Affiliations

  1. Department of Family Medicine, Chung-Ang University Hospital, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, South Korea

    Seonah Kim

  2. Department of Neurology, Daejeon Eulji University college of Medicine, 95, Dunsanseo-ro, Seo-gu, Daejeon, 35233, South Korea

    Jin Ok Kim

  3. Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea

    Kyoung Ja Kwon & Seol-Heui Han

  4. Department of Neurology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea

    Seol-Heui Han & Yeonsil Moon

  5. Research Institute of Medical Science, Konkuk University of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea

    Yeonsil Moon

Authors
  1. Seonah Kim
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  2. Jin Ok Kim
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Correspondence to Yeonsil Moon.

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All the patients provided written informed consent to the use of the data obtained in this study, and this study was approved through the Institutional Review Board of Konkuk University Medical Center (KUH1170159).

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Kim, S., Kim, J.O., Kwon, K.J. et al. Associations of truncal body composition with cognitive status in patients with dementia. Neurol Sci 42, 209–214 (2021). https://doi.org/10.1007/s10072-020-04503-5

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  • DOI: https://doi.org/10.1007/s10072-020-04503-5

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