Various animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be highlighted. Dexketoprofen (DEX) provides a broad antinociceptive profile in different types of pain; therefore, this study was designed to evaluate the profile of antinociceptive potency in mice. Analgesic activity was evaluated using the acetic acid abdominal constriction test (writhing test), a chemical model of visceral pain. Dose-response curves for i.p. DEX administration (1, 3, 10, 30 and 100 mg/kg), using at least six mice in each of at least five doses, was obtained before and 30 min after pre-treatment with different pharmacological agents. Pretreatment of the mice with opioid receptor antagonists was not effective; however, the serotonin receptor antagonist and nitric oxide synthase inhibitor produce a significant increase in DEX-induced antinociception. The data from the present study shows that DEX produces antinociception in the chemical twisting test of mice, which is explained with difficulty by the simple inhibition of COX. This effect appears to be mediated by other mechanisms in which the contribution of the NO and 5-HT pathways has an important effect on DEX-induced antinociception.

中文翻译：

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参与右酮洛芬镇痛小鼠内脏痛的受体

由于在人类中研究疼痛的难度，各种动物模型，尤其是啮齿动物，被用于研究疼痛。已经研究了许多产生镇痛作用的药物，并且有证据表明其中 NSAIDs 值得强调。右酮洛芬 (DEX) 在不同类型的疼痛中提供广泛的镇痛作用；因此，本研究旨在评估小鼠的镇痛效力。使用醋酸腹部收缩试验（扭体试验）评估镇痛活性，这是一种内脏疼痛的化学模型。在用不同药理学试剂预处理之前和之后 30 分钟，获得 ip DEX 给药（1、3、10、30 和 100 mg/kg）的剂量-反应曲线，在至少五个剂量的每一个中使用至少六只小鼠. 用阿片受体拮抗剂预处理小鼠无效；然而，血清素受体拮抗剂和一氧化氮合酶抑制剂显着增加了 DEX 诱导的镇痛作用。本研究的数据表明，DEX 在小鼠的化学扭曲试验中产生镇痛作用，这很难用简单的 COX 抑制来解释。这种作用似乎是由其他机制介导的，其中 NO 和 5-HT 途径的贡献对 DEX 诱导的抗伤害感受有重要影响。