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Receptors involved in dexketoprofen analgesia in murine visceral pain

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Abstract

Various animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be highlighted. Dexketoprofen (DEX) provides a broad antinociceptive profile in different types of pain; therefore, this study was designed to evaluate the profile of antinociceptive potency in mice. Analgesic activity was evaluated using the acetic acid abdominal constriction test (writhing test), a chemical model of visceral pain. Dose-response curves for i.p. DEX administration (1, 3, 10, 30 and 100 mg/kg), using at least six mice in each of at least five doses, was obtained before and 30 min after pre-treatment with different pharmacological agents. Pretreatment of the mice with opioid receptor antagonists was not effective; however, the serotonin receptor antagonist and nitric oxide synthase inhibitor produce a significant increase in DEX-induced antinociception. The data from the present study shows that DEX produces antinociception in the chemical twisting test of mice, which is explained with difficulty by the simple inhibition of COX. This effect appears to be mediated by other mechanisms in which the contribution of the NO and 5-HT pathways has an important effect on DEX-induced antinociception.

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Authors and Affiliations

  1. Cardiovascular Department, Clinical Hospital, Universidad de Chile, Santiago, Chile

    V Noriega & J C Prieto

  2. Facultad de Medicina, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile

    V Noriega

  3. Pharmacology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile

    F Sierralta & J C Prieto

  4. Clínica Alemana, Santiago, Chile

    P Poblete

  5. Neuroscience Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile

    N Aranda & H F Miranda

  6. Laboratorio de Neuroquímica y Neurofarmacología, Centro de Neurobiología y Fisiopatología Integrativa, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaiso, Chile

    R Sotomayor-Zárate

Authors
  1. V Noriega
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  2. F Sierralta
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  3. P Poblete
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  4. N Aranda
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  5. R Sotomayor-Zárate
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  6. J C Prieto
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  7. H F Miranda
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Corresponding author

Correspondence to H F Miranda.

Additional information

Communicated by BJ RAO.

Corresponding editor: BJ Rao

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Noriega, V., Sierralta, F., Poblete, P. et al. Receptors involved in dexketoprofen analgesia in murine visceral pain. J Biosci 45, 94 (2020). https://doi.org/10.1007/s12038-020-00064-z

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  • DOI: https://doi.org/10.1007/s12038-020-00064-z

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