Recognition triggered assembly of split aptamers to initiate a hybridization chain reaction for wash-free and amplified detection of exosomes.,Chemical Communications

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Recognition triggered assembly of split aptamers to initiate a hybridization chain reaction for wash-free and amplified detection of exosomes.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-07-01 , DOI: 10.1039/d0cc02337j
Juan Chen ₁ , Jinlu Tang , Hong-Min Meng , Zhuo Liu , Lin Wang , Xin Geng , Yanan Wu , Lingbo Qu , Zhaohui Li

Affiliation

Here, we develop a facile split aptamer-based system for the amplified, specific and wash-free detection of exosomes in situ assisted by a target-induced hybridization chain reaction (HCR). This design was successfully used to detect target exosomes in a bio-matrix and distinguish cancer patients from healthy individuals.

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