The most common peripheral nervous system manifestations in Sjogren’s syndrome are small fiber sensory neuropathies (SFPN) and axonal sensorimotor polyneuropathies. Currently, treatment in small fiber neuropathy is mainly symptomatic and based on anti-depressors and anti-epileptics. The benefit of treatment with polyvalent immunoglobulins for SFPN has been reported in small series of patients, although transient in several cases. The medium-to-long-term effects of polyvalent immunoglobulins (Ig) in SFPN in patients with Sjogren’s syndrome who are refractory to conventional treatments remain an unmet medical need. We present our experience related to the persistent improvement of Ig in a case series of SFPN in Sjogren’s syndrome and relevant data in the literature regarding the benefits of immunoglobulins, for this indication.

干燥综合征中最常见的周围神经系统表现是小纤维感觉神经病（SFPN）和轴突感觉运动多神经病。当前，小纤维神经病的治疗主要是对症治疗，并以抗抑郁药和抗癫痫药为基础。尽管在某些情况下是短暂的，但已有少量患者报道了用多价免疫球蛋白治疗SFPN的益处。对于传统治疗难以耐受的干燥综合征患者，SFPN中多价免疫球蛋白（Ig）的中长期作用仍未得到满足。我们介绍了有关干燥综合征患者SFPN病例系列中Ig持续改善的经验，以及有关免疫球蛋白益处的文献中有关此指标的相关数据。