Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.

中文翻译：

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从衰老进出。

数十年来，细胞衰老已被公认为稳定抑制细胞增殖。最近的一项研究确定衰老的建立和维持是一个动态的和可逆的过程，该过程受先驱转录因子AP-1控制的预定增强子态的激活（失活）所调节。