Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.
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Zumerle, S., Alimonti, A. In and out from senescence. Nat Cell Biol 22, 753–754 (2020). https://doi.org/10.1038/s41556-020-0540-x
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DOI: https://doi.org/10.1038/s41556-020-0540-x
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