The aim of the study was to elucidate the protective action of roasted Lycium chinense (rLF) enhanced kaempferol glycosides as bioactive components from obese-induced type 2 diabetes mice by investigating the histopathological, biochemical, and transcriptional analyses in blood, liver, and adipose tissue. The rLF extract significantly decreased the hypertrophy of fat deposition, pancreatic hyperplasia, hyperinsulinemia, hepatocellular steatosis, and nephropathy in a dose dependent manner (p < 0.01). However, rLF increased the expression of adiponectin while decreased leptin and sterol response element-binding protein 1c (SREBP1c) expression. rLF also upregulated the expression of AMP-activated protein kinase α1 (AMPKα1) and AMPKα2. The results from this study suggested that rLF extract could be an effective ingredient to prevent obese-induced type 2 diabetes damages by enhancing both adiponectin-induced signaling and AMPK activity in the liver.

该研究的目的是通过研究血液，肝脏和脂肪组织的组织病理学，生化和转录分析，阐明烤枸杞（rLF）增强的山奈酚糖苷作为肥胖诱导的2型糖尿病小鼠的生物活性成分的保护作用。。rLF提取物以剂量依赖性方式显着降低了脂肪沉积，胰腺增生，高胰岛素血症，肝细胞脂肪变性和肾病的肥大（p <0.01）。但是，rLF增加脂联素的表达而瘦素和固醇反应元件结合蛋白1c（SREBP1c）的表达降低。rLF还上调了AMP活化蛋白激酶α1（AMPKα1）和AMPKα2的表达。这项研究的结果表明，rLF提取物可以通过增强脂联素诱导的肝脏信号传导和AMPK活性来预防肥胖引起的2型糖尿病。