Elsevier

Journal of Functional Foods

Volume 72, September 2020, 104072
Journal of Functional Foods

Modulating lipid and glucose metabolism by glycosylated kaempferol rich roasted leaves of Lycium chinense via upregulating adiponectin and AMPK activation in obese mice-induced type 2 diabetes

https://doi.org/10.1016/j.jff.2020.104072Get rights and content
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Highlights

  • Roasted leaves of Lycium chinense (rLF) enhanced glycosylated kaempferol.

  • rLF decreased leptin and sterol response element-binding protein 1c expression.

  • rLF upregulated activity of adiponectin and AMP-activated protein kinase α.

  • It is a potential ingredient to prevent obese-induced type 2 diabetes damages.

Abstract

The aim of the study was to elucidate the protective action of roasted Lycium chinense (rLF) enhanced kaempferol glycosides as bioactive components from obese-induced type 2 diabetes mice by investigating the histopathological, biochemical, and transcriptional analyses in blood, liver, and adipose tissue. The rLF extract significantly decreased the hypertrophy of fat deposition, pancreatic hyperplasia, hyperinsulinemia, hepatocellular steatosis, and nephropathy in a dose dependent manner (p < 0.01). However, rLF increased the expression of adiponectin while decreased leptin and sterol response element-binding protein 1c (SREBP1c) expression. rLF also upregulated the expression of AMP-activated protein kinase α1 (AMPKα1) and AMPKα2. The results from this study suggested that rLF extract could be an effective ingredient to prevent obese-induced type 2 diabetes damages by enhancing both adiponectin-induced signaling and AMPK activity in the liver.

Keywords

The roasted leaves of Lycium chinense
Glycosylated kaempferol
High fat diet obese mice
Anti-obese effect
Adiponectin
AMPK

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