Abstract

A variety of new hybrid derivatives of isoflavone-1,2,3-triazole conjugated heterocycles has been synthesized from 7-hydroxy isoflavone by Cu(I) catalysed azidoalkyne [3+2]cycloaddition. The synthesized compounds have been tested for anti-bacterial activity against gram positive Bacillus subtilis, gram negative Escherichia coli and anti-fungal activity against Sclerotium Rolfsii, Macrophomina phaseolina. Three products demonstrate moderate activity against Bacillus subtilis and three compounds are characterized as highly anti-fungal agents for Sclerotium Rolfsii.

中文翻译：

---

新型异黄酮/ 1,2,3-三唑杂种杂环化合物作为潜在抗菌剂的简便合成

摘要

通过Cu（I）催化的叠氮炔[3 + 2]环加成反应，由7-羟基异黄酮合成了各种异黄酮-1,2,3-三唑共轭杂环新杂合衍生物。已经测试了合成的化合物对革兰氏阳性枯草芽孢杆菌，革兰氏阴性大肠杆菌的抗菌活性以及对罗氏小核菌，菜豆大环孢菌的抗真菌活性。三种产品显示出对枯草芽孢杆菌的中等活性，三种化合物被表征为罗氏菌的高度抗真菌剂。