Skip to main content
SpringerLink
Log in

Facile Synthesis of Novel Isoflavone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

A variety of new hybrid derivatives of isoflavone-1,2,3-triazole conjugated heterocycles has been synthesized from 7-hydroxy isoflavone by Cu(I) catalysed azidoalkyne [3+2]cycloaddition. The synthesized compounds have been tested for anti-bacterial activity against gram positive Bacillus subtilis, gram negative Escherichia coli and anti-fungal activity against Sclerotium Rolfsii, Macrophomina phaseolina. Three products demonstrate moderate activity against Bacillus subtilis and three compounds are characterized as highly anti-fungal agents for Sclerotium Rolfsii.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Scheme 1.
Scheme

Similar content being viewed by others

REFERENCES

  1. Yang, S., Wang, L., Yan, Q., Jiang, Z., and Li, L., Food Chem., 2009, vol. 115, p. 1247. https://doi.org/10.1016/j.foodchem.2009.01.038

    Article  CAS  Google Scholar 

  2. Zubik, L. and Meydani, M., Am. J. Clin. Nutr., 2003, vol. 77, p. 1459. https://doi.org/10.1093/ajcn/77.6.1459

  3. Yoon, G.-A. and Park, S., Nutr. Res. Pract., 2014, vol. 8, p. 618. https://doi.org/10.4162/nrp.2014.8.6.618

  4. Singh, H. and Pratap, R., Tetrahedron Lett., 2006, vol. 47, p. 8161. https://doi.org/10.1016/j.tetlet.2006.09.034.

    Article  CAS  Google Scholar 

  5. Mahesh, K.Z., Debasis, N., Ram, A.V., Parduman, R.S., Anindya, G., and Asif, A., Eur. J. Med. Chem., 2014, vol. 77, p. 47. https://doi.org/10.1016/j.ejmech.2014.02.030

    Article  CAS  Google Scholar 

  6. Barral, K., Moorhouse, A.D., and Moses, J., Org. Lett., 2007, vol. 9, p. 1809. https://doi.org/10.1021/ol070527h

    Article  CAS  PubMed  Google Scholar 

  7. Balouiri, M., Sadiki, M., and Ibnsouda, S.K., J. Pharm. Anal., 2016, vol. 6, p. 71. https://doi.org/10.1016/j.jpha.2015.11.005

    Article  PubMed  Google Scholar 

Download references

ACKNOWLEDGMENTS

The authors are thankful to the Head, Department of Chemistry, Osmania University, Hyderabad, for providing Laboratory facilities and the Director, CFRD, Osmania University, Hyderabad, for providing spectral analysis facilities.

Author information

Authors and Affiliations

  1. Department of Chemistry, Osmania University, 500004, Hyderabad, India

    J. Rao Yerrabelly & Pradeep Mallepaka

Authors
  1. J. Rao Yerrabelly
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pradeep Mallepaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. Rao Yerrabelly.

Ethics declarations

No conflict of interest was declared by the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yerrabelly, J.R., Mallepaka, P. Facile Synthesis of Novel Isoflavone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents. Russ J Gen Chem 90, 911–916 (2020). https://doi.org/10.1134/S1070363220050266

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363220050266

Keywords:

Search

Navigation