Abstract

Some novel isoxazole derivatives of 4-[5-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic acid bearing biologically active pharmacophores like benzodioxane and peptide bond have been synthesized, and their structures are supported by FTIR,¹H and ¹³C NMR, and mass spectra. The title compounds have been tested for antimicrobial and antioxidant activities. Molecular docking of the structures has also been carried out with protein Sortase A, according to which some compounds are characterized as potentially antimicrobial agents. Four products demonstrate strong antioxidant activity.

中文翻译：

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4- [5-（2,3-二氢苯并[b] [1,4]二恶英-7-基）异恶唑-3-基]苯甲酸的一些新型衍生物的合成及生物活性

摘要

合成了一些新型的4- [5-（2,3-二氢苯并[ b ] [1,4]二恶英-7-基）异恶唑-3-基]苯甲酸的异恶唑衍生物，其具有生物活性药效团，如苯并二恶烷和肽键，其结构由FTIR，¹ H和¹³ C NMR和质谱支持。已经测试了标题化合物的抗微生物和抗氧化活性。还已经用蛋白分选酶A进行了结构的分子对接，据此将某些化合物表征为潜在的抗微生物剂。四种产品显示出强大的抗氧化活性。