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Synthesis and Biological Activity of Some Novel Derivatives of 4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid

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Abstract

Some novel isoxazole derivatives of 4-[5-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic acid bearing biologically active pharmacophores like benzodioxane and peptide bond have been synthesized, and their structures are supported by FTIR,1H and 13C NMR, and mass spectra. The title compounds have been tested for antimicrobial and antioxidant activities. Molecular docking of the structures has also been carried out with protein Sortase A, according to which some compounds are characterized as potentially antimicrobial agents. Four products demonstrate strong antioxidant activity.

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ACKNOWLEDGMENTS

The authors sincerely express their gratitude to the management of Vasudha Pharma Chem Ltd., for their encouragement and for providing state of the art facility lab to complete the research work. The authors also express their sincere thanks to Dr. Raghuram Suraparaju (Head, R&D), S. Seshagiri Rao (Manager, R&D) of Vasudha Pharma Chem Ltd. for their support. The authors further express their gratitude to the management of Pragati Engineering College (Autonomous), Surampalem for their cooperation in completing the research work.

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Correspondence to P. V. S. Machiraju.

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Pothuri, V.V., Machiraju, P.V.S. & Rao, V.S.S. Synthesis and Biological Activity of Some Novel Derivatives of 4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid. Russ J Gen Chem 90, 889–894 (2020). https://doi.org/10.1134/S1070363220050229

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  • DOI: https://doi.org/10.1134/S1070363220050229

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