Ischemia–reperfusion (I/R) injury is common during surgery and often results in organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well understood. RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such as immunity, response to DNA damage, tumorigenesis, metastasis, stem cell renewal, fat differentiation, circadian rhythms, cell development and differentiation, and cell division. Research on RNA modifications, specifically N6-methyladenosine (m⁶A), have confirmed that they are involved in the regulation of organ I/R injury. In this review, we summarized current understanding of the regulatory roles and significance of m⁶A RNA methylation in I/R injury in different organs.

缺血再灌注（I/R）损伤在手术过程中很常见，并且常常导致器官功能障碍。 I/R 损伤的机制复杂、多样，且尚不清楚。 RNA甲基化是一种新型表观遗传修饰，参与多种生物过程的调节，如免疫、DNA损伤反应、肿瘤发生、转移、干细胞更新、脂肪分化、昼夜节律、细胞发育和分化以及细胞分裂。对 RNA 修饰（特别是 N6-甲基腺苷 (m ⁶ A)）的研究已证实它们参与器官 I/R 损伤的调节。在这篇综述中，我们总结了目前对 m ⁶ A RNA 甲基化在不同器官 I/R 损伤中的调节作用和意义的理解。