This study aimed to assess the effects of 8-week administration of pomegranate peel extract (PPE, ~180 mg ellagic acid) and vitamin E (Vit E, 400 IU) alone and in combination on oxidative stress (OS) and antioxidative capacity of hemodialysis (HD) patients. One hundred HD patients randomly divided in to 4 groups (control, PPE, Vit E, and PPE + Vit E). The changes of malondialdehyde, oxidized low-density lipoprotein, and myeloperoxidase in PPE + Vit E, PPE, and Vit E groups were significantly different compared to placebo group. The Changes of advanced oxidation protein products, superoxide dismutase, and oxygen radical absorbance capacity in PPE + Vit E group and changes of protein carbonyls in PPE and PPE + Vit E groups were significantly different compared to the other groups. As a result, consumption of PPE combined with Vit E was more effective than PPE or Vit E alone to ameliorate OS and enhance antioxidative capacity of HD patients.

这项研究旨在评估石榴皮提取物（PPE，〜180 mg鞣花酸）和维生素E（Vit E，400 IU）单独和组合使用8周对氧化应激（OS）和血液透析抗氧化能力的影响（HD）患者。一百名HD患者随机分为4组（对照组，PPE，Vit E和PPE + Vit E）。PPE + Vit E，PPE和Vit E组丙二醛，氧化型低密度脂蛋白和髓过氧化物酶的变化与安慰剂组相比有显着差异。PPE + Vit E组的高级氧化蛋白质产物，超氧化物歧化酶和氧自由基吸收能力的变化以及PPE和PPE + Vit E组的蛋白质羰基的变化与其他组相比有显着差异。结果是，