Effects of pomegranate peel extract and vitamin E on oxidative stress and antioxidative capacity of hemodialysis patients: A randomized controlled clinical trial
Oxidative stress is high in hemodialysis (HD) patients and antioxidative defense is disrupted.
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Pomegranate peel extract + vitamin E ameliorates oxidative stress condition of HD patients.
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Pomegranate peel extract + vitamin E enhances antioxidative capacity of HD patients.
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The combination therapy is more effective than the single therapy.
Abstract
This study aimed to assess the effects of 8-week administration of pomegranate peel extract (PPE, ~180 mg ellagic acid) and vitamin E (Vit E, 400 IU) alone and in combination on oxidative stress (OS) and antioxidative capacity of hemodialysis (HD) patients. One hundred HD patients randomly divided in to 4 groups (control, PPE, Vit E, and PPE + Vit E). The changes of malondialdehyde, oxidized low-density lipoprotein, and myeloperoxidase in PPE + Vit E, PPE, and Vit E groups were significantly different compared to placebo group. The Changes of advanced oxidation protein products, superoxide dismutase, and oxygen radical absorbance capacity in PPE + Vit E group and changes of protein carbonyls in PPE and PPE + Vit E groups were significantly different compared to the other groups. As a result, consumption of PPE combined with Vit E was more effective than PPE or Vit E alone to ameliorate OS and enhance antioxidative capacity of HD patients.
