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NMR resonance assignments of the programmed cell death protein 5 (PDCD5) from Toxoplasma gondii.
Biomolecular NMR Assignments ( IF 0.8 ) Pub Date : 2020-06-23 , DOI: 10.1007/s12104-020-09961-8
Meng-Hsuan Lin , Tsun-Ai Yu , Chi-Fon Chang , Yoshifumi Nishikawa , Chun-Hua Hsu

Toxoplasmosis is a systematic protozoan disease caused by a tiny parasite Toxoplasma gondii. The infection can be dangerous for pregnant woman and people with weak immune systems. The secreted protein named TgPDCD5 (Programmed cell death protein 5 from Toxoplasma gondii) plays an important role in apoptosis-inducing effect on host cells. Here, we report the 1H, 13C, and 15N resonance assignments of TgPDCD5. This work provides the ground for further structural elucidate and biophysical investigation about protein function.

中文翻译:

来自弓形虫的程序性细胞死亡蛋白 5 (PDCD5) 的 NMR 共振分配。

弓形虫病是一种由微小寄生虫弓形虫引起的系统性原生动物疾病。这种感染对孕妇和免疫系统较弱的人来说可能是危险的。名为 TgPDCD5 的分泌蛋白(来自弓形虫的程序性细胞死亡蛋白 5 )在对宿主细胞的凋亡诱导作用中起重要作用。在这里,我们报告了TgPDCD5的1 H、13 C 和15 N 共振分配。这项工作为进一步对蛋白质功能进行结构阐明和生物物理学研究奠定了基础。
更新日期:2020-06-23
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