The aim of this study was to estimate the effects of natural low mineral water from the source "Sneznik-1/79" in Serbia on glycemia as well as heart function in rats with diabetes mellitus type 2 (T2DM), with the special emphasis on the role of the oxidative stress. Twenty Wistar albino rats (males, 4 weeks old at the beginning of the study, body weight 180 ± 20 g) were included in the study. Rats were divided randomly into 2 groups (10 animals per group): T2DM: rats with diabetes mellitus type 2 with free access to tap water; T2DM + SW: rats with diabetes mellitus type with free access to natural mineral water from "Sneznik-1/79". Glucose level, ex vivo cardiac function as well as systemic and cardiac redox state were assessed. At the end of the study protocol, glucose level was lower in diabetic rats who consumed mineral water. Moreover cardiac function wasn't affected by mineral water intake, however, significant antioxidant effects were observed. Our study suggests that 4-week consumption of low mineral water from the spring "Sneznik-1/79" has important role in regulation of glycemia and altering redox state in favor of elevated antioxidant capacity without affecting heart function. Based on our findings we may assume that low mineral water from the spring "Sneznik-1/79" has the potential to be used either as preventive strategy or as additional therapeutic strategy in management of T2DM.

中文翻译：

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低矿物质含量水对糖尿病大鼠心功能的影响：关注氧化应激。


本研究的目的是评估来自塞尔维亚“Sneznik-1/79”水源的天然低矿泉水对 2 型糖尿病 (T2DM) 大鼠的血糖和心脏功能的影响，特别强调氧化应激的作用。本研究纳入20只Wistar白化大鼠（雄性，研究开始时4周大，体重180±20g）。将大鼠随机分为2组（每组10只）： T2DM：2型糖尿病大鼠，可自由饮用自来水； T2DM + SW：患有糖尿病型的大鼠，可免费饮用来自“Sneznik-1/79”的天然矿泉水。评估血糖水平、离体心脏功能以及全身和心脏氧化还原状态。在研究方案结束时，饮用矿泉水的糖尿病大鼠的血糖水平较低。此外，心脏功能不受矿泉水摄入的影响，但观察到显着的抗氧化作用。我们的研究表明，连续 4 周饮用“Sneznik-1/79”泉水的低矿泉水对于调节血糖和改变氧化还原状态以提高抗氧化能力而不影响心脏功能具有重要作用。根据我们的研究结果，我们可以假设来自“Sneznik-1/79”泉水的低矿泉水有可能用作 T2DM 管理的预防策略或附加治疗策略。