OBJECTIVE To elevate safety and efficacy of en bloc transurethral resection with 980 nm laser as treatment for primary non-muscle-invasive bladder cancer (NMIBC). METHODS Total 84 cases were enrolled in this study. Among them, 36 and 48 cases underwent treatment using the 980 nm laser and the traditional TUR-BT procedure, respectively. The peri-operative characteristics (tumor size, tumor multiplicity, tumor grade, etc.) and intra-operative complications (obturator nerve reflex, bladder perforation, bladder irrigation, etc.) were recorded and compared between the two groups. RESULTS There are no significant difference in baseline characteristics between laser and TUR-Bt treatment groups. Operation time also has no significant difference in two groups. Obturator nerve reflex and bladder perforation were noted in 6 patients and in 3 patients during TUR-Bt group, respectively. No obturator nerve reflex and bladder perforation were observed in the laser group. The patients who need bladder irrigation was lower in laser group than in TUR-Bt group. There were no significant differences in catheterization time and hospitalization time between two groups. No significant difference in the overall recurrence rate were observed among the two groups during the follow-up periods. CONCLUSION En bloc transurethral resection using 980 nm laser is an effective and safe treatment option for non-muscle-invasive bladder cancer. Compared to the traditional TUR-Bt procedure, the procedure using 980 nm laser has fewer perioperative complications and similar oncological results.

中文翻译：

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980 nm激光整块电切术治疗原发性非肌层浸润性膀胱癌的临床研究

目的 提高 980 nm 激光整块经尿道切除术治疗原发性非肌层浸润性膀胱癌 (NMIBC) 的安全性和有效性。方法本研究共纳入84例。其中，36例和48例分别接受了980 nm激光和传统TUR-BT手术治疗。记录并比较两组的围手术期特征（肿瘤大小、肿瘤多样性、肿瘤分级等）和术中并发症（闭孔神经反射、膀胱穿孔、膀胱冲洗等）。结果 激光和 TUR-Bt 治疗组之间的基线特征没有显着差异。两组手术时间也无显着差异。TUR-Bt组分别有6例患者和3例患者出现闭孔神经反射和膀胱穿孔。激光组未见闭孔神经反射及膀胱穿孔。激光组需要膀胱冲洗的患者低于TUR-Bt组。两组间导尿时间和住院时间无显着差异。随访期间两组的总体复发率无显着差异。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。激光组未见闭孔神经反射及膀胱穿孔。激光组需要膀胱冲洗的患者低于TUR-Bt组。两组间导尿时间和住院时间无显着差异。随访期间两组的总体复发率无显着差异。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。激光组未见闭孔神经反射及膀胱穿孔。激光组需要膀胱冲洗的患者低于TUR-Bt组。两组导尿时间和住院时间无显着差异。随访期间两组的总体复发率无显着差异。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。两组间导尿时间和住院时间无显着差异。随访期间两组的总体复发率无显着差异。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。两组间导尿时间和住院时间无显着差异。随访期间两组的总体复发率无显着差异。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。结论 使用 980 nm 激光整块经尿道切除术是治疗非肌肉浸润性膀胱癌的有效且安全的治疗选择。与传统的 TUR-Bt 手术相比，使用 980 nm 激光的手术围手术期并发症更少，肿瘤学结果相似。