Affiliations: [a] Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou, China
| [b] Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA
Correspondence:
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Corresponding authors: Boxin Xue and Dongrong Yang, Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou, China. Tel.: +86 0 18994392817; E-mail: [email protected] (Boxin Xue); Tel.: +86 13862565799; E-mail: [email protected] (Dongrong Yang).
Note: [1] Co-first-author: Chuanyang Sun, Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou, China. Tel.: +86 0 13962127539; E-mail: [email protected].
Abstract: OBJECTIVE:To elevate safety and efficacy of en bloc transurethral resection with 980 nm laser as treatment for primary non-muscle-invasive bladder cancer (NMIBC). METHODS:Total 84 cases were enrolled in this study. Among them, 36 and 48 cases underwent treatment using the 980 nm laser and the traditional TUR-BT procedure, respectively. The peri-operative characteristics (tumor size, tumor multiplicity, tumor grade, etc.) and intra-operative complications (obturator nerve reflex, bladder perforation, bladder irrigation, etc.) were recorded and compared between the two groups. RESULTS:There are no significant difference in baseline characteristics between laser and TUR-Bt treatment groups. Operation time also has no significant difference in two groups. Obturator nerve reflex and bladder perforation were noted in 6 patients and in 3 patients during TUR-Bt group, respectively. No obturator nerve reflex and bladder perforation were observed in the laser group. The patients who need bladder irrigation was lower in laser group than in TUR-Bt group. There were no significant differences in catheterization time and hospitalization time between two groups. No significant difference in the overall recurrence rate were observed among the two groups during the follow-up periods. CONCLUSION:En bloc transurethral resection using 980 nm laser is an effective and safe treatment option for non-muscle-invasive bladder cancer. Compared to the traditional TUR-Bt procedure, the procedure using 980 nm laser has fewer perioperative complications and similar oncological results.
Keywords: 980 nm laser, non-muscle invasive bladder cancer, en Bloc
