Oral lichen planus (OLP) is a relatively common chronic inflammatory disease. The micronutrients are critical factors in health of oral mucous and proper function of immune system. There have not been any review articles for evaluating trace element levels before and after standard treatments of OLP. The purpose of this study is to provide complete review of the association of micronutrients with OLP. Databases including PubMed, Google Scholar, Scopus, and Embase (Ovid) with keywords of oral lichen planus, OLP, oral disorder, micronutrients, trace element, nutrient element, antioxidant, oxidative stress, malnutrition, and essential trace elements, without time limitation (1900-2019) were searched to collect data on related articles. Total number of 58 original articles including 12 randomized clinical trials, 41 case-control, 4 case reports, and 1 cell line research were reviewed in this study. Lower levels of iron and its associated markers, such as hemoglobin and ferritin, increased levels of TIBC; reduced levels of zinc, calcium, vitamin D, vitamin B12, folic acid, and antioxidants such as vitamins C and E; and increased levels of oxidants and homocysteine, have been reported in OLP patients.

中文翻译：

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口腔扁平苔藓的微量营养素概况：综述文献。

口腔扁平苔藓（OLP）是一种比较常见的慢性炎症性疾病。微量营养素是口腔黏液健康和免疫系统正常功能的关键因素。没有任何评价 OLP 标准治疗前后微量元素水平的评论文章。本研究的目的是全面回顾微量营养素与 OLP 的关系。包括 PubMed、Google Scholar、Scopus 和 Embase (Ovid) 的数据库，关键词为口腔扁平苔藓、OLP、口腔疾病、微量营养素、微量元素、营养元素、抗氧化剂、氧化应激、营养不良和必需微量元素，没有时间限制（ 1900-2019）被搜索以收集相关文章的数据。原创文章总数58篇，其中随机临床试验12篇，病例对照41篇，病例报告4篇，本研究回顾了 1 项细胞系研究。较低水平的铁及其相关标志物，如血红蛋白和铁蛋白，会增加 TIBC 的水平；锌、钙、维生素 D、维生素 B12、叶酸和抗氧化剂（如维生素 C 和 E）水平降低；据报道，OLP 患者的氧化剂和同型半胱氨酸水平升高。